@article{ISI:000395060400010,
 abstract = {Nonlinear waves of the reaction-diffusion (RD) type occur in many
biophysical systems, including the heart, where they initiate cardiac
contraction. Such waves can form vortices called scroll waves, which
result in the onset of life-threatening cardiac arrhythmias. The
dynamics of scroll waves is affected by the presence of inhomogeneities,
which, in a very general way, can be of (i) ionic type; i.e., they
affect the reaction part, or (ii) conduction type, i.e., they affect the
diffusion part of an RD-equation. We demonstrate, for the first time, by
using a state-of-the-art, anatomically realistic model of the pig heart,
how differences in the geometrical and biophysical nature of such
inhomogeneities can influence scroll-wave dynamics in different ways.
Our study reveals that conduction-type inhomogeneities become
increasingly important at small length scales, i.e., in the case of
multiple, randomly distributed, obstacles in space at the cellular scale
(0.2-0.4 mm). Such configurations can lead to scroll-wave break up. In
contrast, ionic inhomogeneities affect scroll-wave dynamics
significantly at large length scales, when these inhomogeneities are
localized in space at the tissue level (5-10 mm). In such
configurations, these inhomogeneities can attract scroll waves, by
pinning them to the heterogeneity, or lead to scroll-wave breakup.},
 author = {Majumder, R. and Pandit, R. and Panfilov, A. V.},
 doi = {10.1134/S0021364016230041},
 eissn = {1090-6487},
 issn = {0021-3640},
 journal = {JETP LETTERS},
 month = {DEC},
 number = {11},
 orcid-numbers = {Panfilov, Alexander/0000-0003-2643-642X},
 pages = {796-799},
 researcherid-numbers = {Panfilov, Alexander/G-8459-2016},
 times-cited = {2},
 title = {Scroll-Wave Dynamics in the Presence of Ionic and Conduction
Inhomogeneities in an Anatomically Realistic Mathematical Model for the
Pig Heart},
 unique-id = {ISI:000395060400010},
 volume = {104},
 year = {2016}
}