@article{ISI:000329994200005,
 abstract = {The cell nucleus functions amidst active cytoskeletal filaments, but its
response to their contractile stresses is largely unexplored. We study
the dynamics of the nuclei of single fibroblasts, with cell migration
suppressed by plating onto micro-fabricated patterns. We find the
nucleus undergoes noisy but coherent rotational motion. We account for
this observation through a hydrodynamic approach, treating the nucleus
as a highly viscous inclusion residing in a less viscous fluid of
orientable filaments endowed with active stresses. Lowering actin
contractility selectively by introducing blebbistatin at low
concentrations drastically reduced the speed and coherence of the
angular motion of the nucleus. Time-lapse imaging of actin revealed a
correlated hydrodynamic flow around the nucleus, with profile and
magnitude consistent with the results of our theoretical approach.
Coherent intracellular flows and consequent nuclear rotation thus appear
to be an intrinsic property of cells.},
 article-number = {3781},
 author = {Kumar, Abhishek and Maitra, Ananyo and Sumit, Madhuresh and Ramaswamy,
Sriram and Shivashankar, G. V.},
 doi = {10.1038/srep03781},
 issn = {2045-2322},
 journal = {SCIENTIFIC REPORTS},
 month = {JAN 21},
 orcid-numbers = {Kumar, Abhishek/0000-0003-3235-1916
Maitra, Ananyo/0000-0003-3701-6981
Sumit, Madhuresh/0000-0002-2268-2335},
 researcherid-numbers = {Kumar, Abhishek/F-3498-2018
},
 times-cited = {36},
 title = {Actomyosin contractility rotates the cell nucleus},
 unique-id = {ISI:000329994200005},
 volume = {4},
 year = {2014}
}