@article{ISI:000266354600005,
 abstract = {We report a pH-dependent conformational transition in short, defined
homopolymeric deoxyadenosines (dA(15)) from a single helical structure
with stacked nucleobases at neutral pH to a double-helical,
parallel-stranded duplex held together by AH-HA base pairs at acidic pH.
Using native PAGE, 2D NMR, circular dichroism (CD) and fluorescence
spectroscopy, we have characterized the two different pH dependent forms
of dA(15). The pH-triggered transition between the two defined helical
forms of dA(15) is characterized by CD and fluorescence. The kinetics of
this conformational switch is found to occur on a millisecond time
scale. This robust, highly reversible, pH-induced transition between the
two well-defined structured states of dA(15) represents a new molecular
building block for the construction of quick-response, pH-switchable
architectures in structural DNA nanotechnology.},
 author = {Chakraborty, Saikat and Sharma, Suruchi and Maiti, Prabal K. and
Krishnan, Yamuna},
 doi = {10.1093/nar/gkp133},
 eissn = {1362-4962},
 issn = {0305-1048},
 journal = {NUCLEIC ACIDS RESEARCH},
 month = {MAY},
 number = {9},
 orcid-numbers = {Maiti, Prabal/0000-0002-9956-1136
Chakraborty, Saikat/0000-0002-6307-8441},
 pages = {2810-2817},
 researcherid-numbers = {Maiti, Prabal/B-6335-2009
},
 times-cited = {81},
 title = {The poly dA helix: a new structural motif for high performance DNA-based
molecular switches},
 unique-id = {ISI:000266354600005},
 volume = {37},
 year = {2009}
}