@article{ISI:000245302400003,
 abstract = {Objective: To investigate the changes in B-type natriuretic peptide
concentrations in patients with severe sepsis and septic shock and to
investigate the value of B-type natriuretic peptide in predicting
intensive care unit outcomes.
Design: Prospective observational study.
Setting. General intensive care unit.
Patients: Forty patients with severe sepsis or septic shock.
Interventions. None.
Measurements and Main Results: B-type natriuretic peptide measurements
and echocardiography were carried out daily for 10 consecutive days.
In-hospital mortality and length of stay were recorded. The admission
B-type natriuretic peptide concentrations were generally increased (747
+/- 860 pg/mL). B-type natriuretic peptide levels were elevated in
patients with normal left ventricular systolic function (568 +/- 811
pg/mL), with sepsis-related reversible cardiac dysfunction (630 +/- 726
pg/mL), and with chronic cardiac dysfunction (1311 +/- 1097 pg/mL).
There were no significance changes in B-type natriuretic peptide levels
over the 10-day period. The daily B-type natriuretic peptide
concentrations for the first 3 days neither predicted in-hospital
mortality nor correlated with length of intensive care unit or hospital
stay.
Conclusion: B-type natriuretic peptide concentrations were increased in
patients with severe sepsis or septic shock regardless of the presence
or absence of cardiac dysfunction. Neither the B-type natriuretic
peptide levels for the first 3 days nor the daily changes in B-type
natriuretic peptide provided prognostic value for in-hospital mortality
and length of stay in this mixed group of patients, which included
patients with chronic cardiac dysfunction.},
 author = {McLean, Anthony S. and Huang, Stephen J. and Hyams, Stephanie and Poh,
Genie and Nalos, Marek and Pandit, Rahul and Balik, Martin and Tang, Ben
and Seppelt, Ian},
 doi = {10.1097/01.CCM.0000259469.24364.31},
 issn = {0090-3493},
 journal = {CRITICAL CARE MEDICINE},
 month = {APR},
 number = {4},
 orcid-numbers = {Huang, Stephen/0000-0003-2518-0506
Nalos, Marek/0000-0002-7977-9410},
 pages = {1019-1026},
 researcherid-numbers = {Huang, Stephen/O-6195-2019
},
 times-cited = {70},
 title = {Prognostic values of B-type natriuretic peptide in severe sepsis and
septic shock},
 unique-id = {ISI:000245302400003},
 volume = {35},
 year = {2007}
}